Let KAYAK do the searching
Based on KAYAK hotel searches, the most popular destination is Varadero (49% of total searches to Cuba). The next most popular destinations are Havana (34%) and Cayo Santa Maria (12%). Searches for hotels in Chivirico (5%) are also popular.
Based on KAYAK hotel searches, the most popular region to stay in Cuba is Matanzas. Ciudad de La Habana and Villa Clara are also very popular.